Oncofetal gene SALL4 in aggressive hepatocellular carcinoma

Autoria(s): Yong, Kol Jia; Gao, Chong; Lim, Joline S J; Yan, Benedict; Yang, Henry; Dimitrov, Todor; Kawasaki, Akira; Ong, Chee Wee; Wong, Kwong-Fai; Lee, Sanghoon; Ravikumar, Sharada; Srivastava, Supriya; Tian, Xi; Poon, Ronnie T; Fan, Sheung Tat; Luk, John M; Dan, Yock Young; Salto-Tellez, Manuel; Chai, Li; Tenen, Daniel G
Data(s)

13/06/2013
Resumo

Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. In the heterogeneous group of hepatocellular carcinomas, those with characteristics of embryonic stem-cell and progenitor-cell gene expression are associated with the worst prognosis. The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is associated with a poor prognosis and is a potential target for treatment.
Identificador

http://pure.qub.ac.uk/portal/en/publications/oncofetal-gene-sall4-in-aggressive-hepatocellular-carcinoma(399d2cac-cbee-4547-809e-074e983e6cc4).html

http://dx.doi.org/10.1056/NEJMoa1300297
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Yong , K J , Gao , C , Lim , J S J , Yan , B , Yang , H , Dimitrov , T , Kawasaki , A , Ong , C W , Wong , K-F , Lee , S , Ravikumar , S , Srivastava , S , Tian , X , Poon , R T , Fan , S T , Luk , J M , Dan , Y Y , Salto-Tellez , M , Chai , L & Tenen , D G 2013 , ' Oncofetal gene SALL4 in aggressive hepatocellular carcinoma ' New England Journal of Medicine , vol 368 , no. 24 , pp. 2266-76 . DOI: 10.1056/NEJMoa1300297
Palavras-Chave #Animals #Carcinoma, Hepatocellular #Metabolic Networks and Pathways #PTEN Phosphohydrolase #Humans #Gene Expression #Prognosis #Mice #Gene Expression Regulation, Neoplastic #Liver Neoplasms #Mice, Inbred Strains #Tumor Cells, Cultured #Transcription Factors #Adult #Liver #Transplantation, Heterologous #Tumor Markers, Biological #/dk/atira/pure/subjectarea/asjc/2700 #Medicine(all)
Tipo

article
Acesso ao item digital