Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate


Autoria(s): Todd, G.; Dunlop, K.; McNaboe, J.; Ryan, M.F.; Carson, D.; Shields, M.D.
Data(s)

06/07/1996

Resumo

Background: Fluticasone propionate was introduced in 1993 in the UK as a potentially safer inhaled corticosteroid than those already in use. The efficacy and safety of fluticasone has been established at recommended doses of 200 µg/day, but not at the higher doses that are often used. <br/><br/>Methods: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder). Assessment of cortisol response was by insulin-induced hypoglycaemia in three cases, by short tetracosactrin test in two, and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one. <br/><br/>Findings: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression. In one case the growth rate and cortisol response returned to normal 9 months after the fluticasone dose was reduced to 500 µg/day. <br/><br/>Interpretation: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.

Formato

application/pdf

Identificador

http://pure.qub.ac.uk/portal/en/publications/growth-and-adrenal-suppression-in-asthmatic-children-treated-with-highdose-fluticasone-propionate(3a7114da-d892-4b97-a879-a8d8000b1faf).html

http://dx.doi.org/10.1016/S0140-6736(96)03339-9

http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-0030572466&md5=5e8d587dd0d9bd43b7b4949f2fe7696c

http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-0030572466&md5=5e8d587dd0d9bd43b7b4949f2fe7696c

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Todd , G , Dunlop , K , McNaboe , J , Ryan , M F , Carson , D & Shields , M D 1996 , ' Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate ' Lancet , vol 348 , no. 9019 , pp. 27-29 . DOI: 10.1016/S0140-6736(96)03339-9

Tipo

article