Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
Data(s) |
15/08/2012
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Resumo |
<p>2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed. (c) 2012 Elsevier Ltd. All rights reserved.</p> |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Midtkandal , R R , Redpath , P , Trammell , S A J , Macdonald , S J F , Brenner , C & Migaud , M E 2012 , ' Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside ' Bioorganic & Medicinal Chemistry Letters , vol 22 , no. 16 , pp. 5204-5207 . DOI: 10.1016/j.bmcl.2012.06.069 |
Palavras-Chave | #C-Nucleoside #Benzamide riboside #Intramolecular cyclisation #Inosine monophosphate dehydrogenase #Nicotinamide adenine dinucleotide #/dk/atira/pure/subjectarea/asjc/3000/3003 #Pharmaceutical Science #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/1300/1313 #Molecular Medicine #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology #/dk/atira/pure/subjectarea/asjc/1300/1308 #Clinical Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry |
Tipo |
article |