Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

Autoria(s): Deranieh, R.M.; Greenberg, M.L.; Le Calvez, P.-B.; Migaud, M.E.; Mooney, M.C.
Data(s)

01/01/2012
Resumo

<p>The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.</p>
Identificador

http://pure.qub.ac.uk/portal/en/publications/probing-myoinositol-1phosphate-synthase-with-multisubstrate-adducts(daa39712-f0cc-4631-a48e-6a8c59022741).html

http://dx.doi.org/10.1039/c2ob26577j

http://www.scopus.com/inward/record.url?eid=2-s2.0-84870014649&partnerID=8YFLogxK
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Deranieh , R M , Greenberg , M L , Le Calvez , P-B , Migaud , M E & Mooney , M C 2012 , ' Probing myo-inositol 1-phosphate synthase with multisubstrate adducts ' Organic and Biomolecular Chemistry , vol 10 , no. 48 , pp. 9601-9619 . DOI: 10.1039/c2ob26577j
Tipo

article
Acesso ao item digital