Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury:efficacy and mechanism
| Data(s) |
01/08/2008
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| Resumo |
We tested our hypothesis that postischemic conditioning (PostC) is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mitochondrial permeability transition pore (mPTP). In bilateral 8x13 cm pig latissimus dorsi muscle flaps subjected to 4 h ischemia, muscle infarction increased from 22+/-4 to 41+/-1% between 2 and 24 h reperfusion and remained unchanged at 48 (38+/-6%) and 72 (40+/-1%) h reperfusion (P |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
McAllister , S E , Ashrafpour , H , Cahoon , N , Huang , N , Moses , M A , Neligan , P C , Forrest , C R , Lipa , J E & Pang , C Y 2008 , ' Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury : efficacy and mechanism ' American journal of physiology. Regulatory, integrative and comparative physiology , vol 295 , no. 2 , pp. R681-9 . DOI: 10.1152/ajpregu.90303.2008 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1314 #Physiology #/dk/atira/pure/subjectarea/asjc/2700/2737 #Physiology (medical) |
| Tipo |
article |
