Helminth pathogen cathepsin proteases:it's a family affair


Autoria(s): Robinson, Mark W; Dalton, John P; Donnelly, Sheila
Data(s)

01/12/2008

Resumo

Helminth pathogens express papain-like cysteine peptidases, termed cathepsins, which have important roles in virulence, including host entry, tissue migration and the suppression of host immune responses. The liver fluke Fasciola hepatica, an emerging human pathogen, expresses the largest cathepsin L cysteine protease family yet described. Recent phylogenetic, biochemical and structural studies indicate that this family contains five separate clades, which exhibit overlapping but distinct substrate specificities created by a process of gene duplication followed by subtle residue divergence within the protease active site. The developmentally regulated expression of these proteases correlates with the passage of the parasite through host tissues and its encounters with different host macromolecules.

Identificador

http://pure.qub.ac.uk/portal/en/publications/helminth-pathogen-cathepsin-proteases(4bfee953-3c5f-47b8-92bc-e799964d62b0).html

http://dx.doi.org/10.1016/j.tibs.2008.09.001

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Robinson , M W , Dalton , J P & Donnelly , S 2008 , ' Helminth pathogen cathepsin proteases : it's a family affair ' Trends in Biochemical Sciences , vol 33 , no. 12 , pp. 601-8 . DOI: 10.1016/j.tibs.2008.09.001

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology
Tipo

article