Mass spectrometric analysis of muscle samples to detect potential antibiotic growth promoter misuse in broiler chickens


Autoria(s): Gibson, R.; Cooper, K. M.; Kennedy, D. G.; Elliott, C. T.
Data(s)

01/06/2012

Resumo

<p>Mass spectrometric methods were developed and validated for the analysis in chicken muscle of a range of antibiotic growth promoters: spiramycin, tylosin, virginiamycin and bacitracin, and separately for two marker metabolites of carbadox (quinoxaline-2-carboxylic acid and 1,4-bisdesoxycarbadox), and a marker metabolite of olaquindox (3-methyl-quinoxaline-2-carboxylic acid). The use of these compounds as antibiotic growth promoters has been banned by the European Commission. This study aimed to develop methods to detect their residues in muscle samples as a means of checking for the use of these drugs during the rearing of broiler chickens. When fed growth-promoting doses for 6 days, spiramycin (31.4 mu g kg(-1)), tylosin (1.0 mu g kg(-1)), QCA (6.5 mu g kg(-1)), DCBX (71.2 mu g kg(-1)) and MQCA (0.2 mu g kg(-1)) could be detected in the muscle 0 days after the withdrawal of fortified feed. Only spiramycin could consistently be detected beyond a withdrawal period of 1 day. All analytes showed stability commercial cooking process, therefore raw or cooked muscle could be used for monitoring purposes.</p>

Identificador

http://pure.qub.ac.uk/portal/en/publications/mass-spectrometric-analysis-of-muscle-samples-to-detect-potential-antibiotic-growth-promoter-misuse-in-broiler-chickens(28abd3f0-ef4e-4698-8e96-f8c048b90bae).html

http://dx.doi.org/10.1080/19440049.2012.698398

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Gibson , R , Cooper , K M , Kennedy , D G & Elliott , C T 2012 , ' Mass spectrometric analysis of muscle samples to detect potential antibiotic growth promoter misuse in broiler chickens ' FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT , vol 29 , no. 9 , 698398 , pp. 1413-1424 . DOI: 10.1080/19440049.2012.698398

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1100/1106 #Food Science #/dk/atira/pure/subjectarea/asjc/2300/2307 #Health, Toxicology and Mutagenesis #/dk/atira/pure/subjectarea/asjc/2700/2739 #Public Health, Environmental and Occupational Health #/dk/atira/pure/subjectarea/asjc/3000/3005 #Toxicology #/dk/atira/pure/subjectarea/asjc/1600 #Chemistry(all)
Tipo

article