Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Autoria(s): Orr, Nick; Lemnrau, Alina; Cooke, Rosie; Fletcher, Olivia; Tomczyk, Katarzyna; Jones, Michael; Johnson, Nichola; Lord, Christopher J; Mitsopoulos, Costas; Zvelebil, Marketa; McDade, Simon S; Buck, Gemma; Blancher, Christine; Trainer, Alison H; James, Paul A; Bojesen, Stig E; Bokmand, Susanne; Nevanlinna, Heli; Mattson, Johanna; Friedman, Eitan; Laitman, Yael; Palli, Domenico; Masala, Giovanna; Zanna, Ines; Ottini, Laura; Giannini, Giuseppe; Hollestelle, Antoinette; Ouweland, Ans M W van den; Novaković, Srdjan; Krajc, Mateja; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Olsson, Håkan; Hedenfalk, Ingrid; Easton, Douglas F; Pharoah, Paul D P; Dunning, Alison M; Bishop, D Timothy; Neuhausen, Susan L; Steele, Linda; Houlston, Richard S; Garcia-Closas, Montserrat; Ashworth, Alan; Swerdlow, Anthony J; KConFab Consortium
Data(s)

23/09/2012
Resumo

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).
Identificador

http://pure.qub.ac.uk/portal/en/publications/genomewide-association-study-identifies-a-common-variant-in-rad51b-associated-with-male-breast-cancer-risk(5f5eb578-7eae-4e0b-a82d-6cc2d13cb47c).html

http://dx.doi.org/10.1038/ng.2417
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Orr , N , Lemnrau , A , Cooke , R , Fletcher , O , Tomczyk , K , Jones , M , Johnson , N , Lord , C J , Mitsopoulos , C , Zvelebil , M , McDade , S S , Buck , G , Blancher , C , Trainer , A H , James , P A , Bojesen , S E , Bokmand , S , Nevanlinna , H , Mattson , J , Friedman , E , Laitman , Y , Palli , D , Masala , G , Zanna , I , Ottini , L , Giannini , G , Hollestelle , A , Ouweland , A M W V D , Novaković , S , Krajc , M , Gago-Dominguez , M , Castelao , J E , Olsson , H , Hedenfalk , I , Easton , D F , Pharoah , P D P , Dunning , A M , Bishop , D T , Neuhausen , S L , Steele , L , Houlston , R S , Garcia-Closas , M , Ashworth , A , Swerdlow , A J & KConFab Consortium 2012 , ' Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk ' Nature Genetics , vol 44 , no. 11 , pp. 1182-4 . DOI: 10.1038/ng.2417
Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1311 #Genetics
Tipo

article
Acesso ao item digital