Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons
| Contribuinte(s) |
Osvay, Karoly Dombi, Peter Fulop, Jozsef Andras Varju, Katalin |
|---|---|
| Data(s) |
09/07/2012
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| Resumo |
<p>The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10<sup>9</sup>Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. </p> |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
AIP Publishing |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Doria , D , Kakolee , K F , Kar , S , Litt , S K , Fiorini , F , Ahmed , H , Green , S , Jeynes , J C G , Kavanagh , J , Kirby , D , Kirkby , K J , Lewis , C L , Merchant , M J , Nersisyan , G , Prasad , R , Prise , K M , Schettino , G , Zepf , M & Borghesi , M 2012 , Biological Cell Irradiation At Ultrahigh Dose Rate Employing Laser Driven Protons . in K Osvay , P Dombi , J A Fulop & K Varju (eds) , AIP Conference Proceedings: Light at Extreme Intensities 2011 . vol. 1462 , AIP Publishing , pp. 135-138 , Conference on Light at Extreme Intensities 2011 , Szeged , Hungary , 14-18 November . DOI: 10.1063/1.4736777 |
| Tipo |
contributionToPeriodical |
