Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains

Autoria(s): Tikhonova, I.G.; Baskin, I.I.; Palyulin, V.A.; Zefirov, N.S.
Data(s)

01/01/2004
Resumo

Using the molecular-graphic complex Sybyl6.7.2, computational construction of spatial models for N-terminal domains (of NR1- and NR2B-subunits) of NMDA-receptor was conducted. On the basis of the constructed models and also CoMFA method the conclusion is made about presence of the binding site for the compounds similar to iphenprodyl in two N-terminal domains of NR1- and NR2B-subunits. The obtained data can be used for constructing new ligands.
Identificador

http://pure.qub.ac.uk/portal/en/publications/molecular-modeling-of-nterminal-domains-of-nmdareceptor-study-of-ligand-binding-with-nterminal-domains(75cf17e3-6907-4c79-8768-64bcd985bb8c).html

http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-12244280186&md5=dee0fcf471426f180be3e33789c1d42f
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Tikhonova , I G , Baskin , I I , Palyulin , V A & Zefirov , N S 2004 , ' Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding with N-terminal domains ' Doklady Akademii nauk SSSR , vol 397 , no. 4 , pp. 549-557 .
Tipo

article
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