Suppressors of cytokine signalling (SOCS): putative modulators of cytokine bioactivity in health and disease
Data(s) |
01/01/2000
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Resumo |
Cytokines are important modulators of homeostatic processes such as development, haematopoiesis and host defence, A recently identified family of proteins, the supressors of cytokine signalling (SOCS) act as negative regulators of the key cytokine-activated signalling pathway, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) cascade, In the current review, the discovery, structural features, regulation of expression, mechanisms of JAK/STAT inhibition and putative role in health and disease of the SOCS family are discussed. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Diamond , J , Doran , P , Brady , J & McGinty , A 2000 , ' Suppressors of cytokine signalling (SOCS): putative modulators of cytokine bioactivity in health and disease ' Journal of Nephrology , vol 13 , no. 1 , pp. 9-14 . |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2727 #Nephrology |
Tipo |
article |