Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways
| Data(s) |
15/01/2012
|
|---|---|
| Resumo |
Purpose: Cancer cells have been shown to be more susceptible to Ran knockdown than normal cells. We nowinvestigate whether Ran is a potential therapeutic target of cancers with frequently found mutations that lead to higher Ras/MEK/ERK [mitogen-activated protein/extracellular signal-regulated kinase (ERK; MEK)] and phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 activities. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Yuen , H-F , Chan , K K , Grills , C , Murray , J T , Platt-Higgins , A , Eldin , O S , O'Byrne , K , Janne , P , Fennell , D A , Johnston , P G , Rudland , P S & El-Tanani , M 2012 , ' Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways ' Clinical Cancer Research , vol 18 , no. 2 , pp. 380-391 . DOI: 10.1158/1078-0432.CCR-11-2035 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology |
| Tipo |
article |
