Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10<sup>9</sup> Gy/s
| Data(s) |
01/03/2012
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| Resumo |
The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. |
| Formato |
application/pdf |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
Doria , D , Kakolee , K F , Kar , S , Litt , S K , Fiorini , F , Ahmed , H , Green , S , Jeynes , J C G , Kavanagh , J , Kirby , D , Kirby , K J , Lewis , C L , Merchant , M J , Nersisyan , G , Prasad , R , Prise , K M , Schettino , G , Zepf , M & Borghesi , M 2012 , ' Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10 9 Gy/s ' AIP Advances , vol 2 , no. 1 , 011209 . DOI: 10.1063/1.3699063 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/3100 #Physics and Astronomy(all) |
| Tipo |
article |
