Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)

Autoria(s): Williams, Richard; Johnson, K.A.; Gentry, P.R.; Niswender, C.M.; Weaver, C.D.; Conn, P.J.; Lindsley, C.W.; Hopkins, C.R.
Data(s)

01/09/2009
Resumo

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041. (C) 2009 Elsevier Ltd. All rights reserved.
Identificador

http://pure.qub.ac.uk/portal/en/publications/synthesis-and-sar-of-a-novel-positive-allosteric-modulator-pam-of-the-metabotropic-glutamate-receptor-4-mglur4(d634c551-59c8-4f4c-99c2-560a1c00cf47).html

http://dx.doi.org/10.1016/j.bmcl.2009.07.072
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Williams , R , Johnson , K A , Gentry , P R , Niswender , C M , Weaver , C D , Conn , P J , Lindsley , C W & Hopkins , C R 2009 , ' Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) ' Bioorganic & Medicinal Chemistry Letters , vol 19 , no. 17 , pp. 4967-4970 . DOI: 10.1016/j.bmcl.2009.07.072
Palavras-Chave #/dk/atira/pure/subjectarea/asjc/3000/3003 #Pharmaceutical Science #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/1300/1313 #Molecular Medicine #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology #/dk/atira/pure/subjectarea/asjc/1300/1308 #Clinical Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry
Tipo

article
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