Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4
| Data(s) |
16/06/2010
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| Resumo |
This paper describes a detailed structure activity relationship (SAR) analysis of the metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator, (-)-N-phenyl-7-(hydroxyimino)cyclopropa[b]-chromen-la-carboxamide (PHCCC). We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Williams , R , Zhou , Y , Niswender , C M , Luo , Q , Conn , P J , Lindsley , C W & Hopkins , C R 2010 , ' Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4 ' ACS chemical neuroscience , vol 1 , no. 6 , pp. 411-419 . DOI: 10.1021/cn9000318 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1307 #Cell Biology #/dk/atira/pure/subjectarea/asjc/1300/1314 #Physiology #/dk/atira/pure/subjectarea/asjc/2800/2805 #Cognitive Neuroscience |
| Tipo |
article |
