Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients


Autoria(s): Collier, Paul; Millership, Jeffrey; Kole, Prashant; Halliday, H.; McElnay, James; Shields, Mike; Suyagh, Maysa; Hawwa, Ahmed; Millar, Muriel
Data(s)

01/11/2012

Resumo

Objectives: To characterize the population pharmacokinetics of canrenone following administration of potassium canrenoate in paediatric patients. Patients and Methods: Data were collected prospectively from 23 paediatric patients (2 days to 10 years of age; median weight 4 kg, range 2.16-28.0 kg) who received intravenous potassium canrenoate (K-canrenoate) as part of their intensive care therapy for removal of retained fluids e.g. in pulmonary oedema due to chronic lung disease and for the management of congestive heart failure. Plasma samples were analysed by HPLC for determination of canrenone (the major metabolite and pharmacologically active moiety) and the data subjected to pharmacokinetic analysis using NONMEM. Results: A one-compartment model best described the data. The only significant covariate was weight (WT). The final population models for canrenone clearance (CL/F) and volume of distribution (V/F) were CL/F (L/hr) = 11.4 × (WT /70.0)(0.75) and V/F (L) = 374.2 × (WT/70) where WT is in kg. The values of CL/F and V/F in a 4 kg child would be 1.33 L/hr and 21.4 L, respectively, resulting in an elimination half-life of 11.2 hr. Conclusions: The range of estimated CL/F in the study population was 0.67-7.38 L/hr. The data suggest that adjustment of K-canrenoate dosage according to body weight is appropriate in paediatric patients

Formato

application/pdf

Identificador

http://pure.qub.ac.uk/portal/en/publications/population-pharmacokinetic-model-of-canrenone-after-intravenous-administration-of-potassium-canrenoate-to-paediatric-patients(ba8ab25b-61a7-4ad6-9d1a-1d0371ac6218).html

http://dx.doi.org/10.1111/j.1365-2125.2012.04257.x

http://pure.qub.ac.uk/ws/files/2525844/Population_pharmacokinetic_model_of_canrenone_after_intravenous_administration_of_potassium_canrenoate_to_paediatric_patients.pdf

http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84867375184&md5=e79813e4ed93485a3cc75c88f5f98018

Idioma(s)

eng

Direitos

info:eu-repo/semantics/openAccess

Fonte

Collier , P , Millership , J , Kole , P , Halliday , H , McElnay , J , Shields , M , Suyagh , M , Hawwa , A & Millar , M 2012 , ' Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients ' British Journal of Clinical Pharmacology , vol 74 , no. 5 , pp. 864-872 . DOI: 10.1111/j.1365-2125.2012.04257.x

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2736 #Pharmacology (medical) #/dk/atira/pure/subjectarea/asjc/3000/3004 #Pharmacology
Tipo

article