Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica


Autoria(s): Robinson, Mark W; Corvo, Ileana; Jones, Peter M; George, Anthony M; Padula, Matthew P; To, Joyce; Cancela, Martin; Rinaldi, Gabriel; Tort, Jose F; Roche, Leda; Dalton, John P
Data(s)

01/04/2011

Resumo

The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2.

Identificador

http://pure.qub.ac.uk/portal/en/publications/collagenolytic-activities-of-the-major-secreted-cathepsin-l-peptidases-involved-in-the-virulence-of-the-helminth-pathogen-fasciola-hepatica(f4ac7f81-7be3-4599-9e62-1e538bb3e7a9).html

http://dx.doi.org/10.1371/journal.pntd.0001012

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Robinson , M W , Corvo , I , Jones , P M , George , A M , Padula , M P , To , J , Cancela , M , Rinaldi , G , Tort , J F , Roche , L & Dalton , J P 2011 , ' Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica ' PLoS neglected tropical diseases , vol 5 , no. 4 , e1012 , pp. e1012 . DOI: 10.1371/journal.pntd.0001012

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2725 #Infectious Diseases #/dk/atira/pure/subjectarea/asjc/2700/2739 #Public Health, Environmental and Occupational Health #/dk/atira/pure/subjectarea/asjc/3000 #Pharmacology, Toxicology and Pharmaceutics(all)
Tipo

article