No Evidence that Extended Tracts of Homozygosity are Associated with Alzheimer’s Disease.

Autoria(s): Sims, Rebecca; Dwyer, Sarah; Harold, Denise; Gerrish, Amy; Hollingworth, Paul; Chapman, Jade; Jones, Nicola; Abraham, Richard; Ivanov, Dobril; Pahwa, Jaspreet Singh; Moskvina, Valentina; Dowzell, Kimberley; Thomas, Charlene; Stretton, Alexandra; Lovestone, Simon; Powell, John; Proitsi, Petroula; Lupton, Michelle K; Brayne, Carol; Rubinsztein, David C; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Brown, Kristelle S; Passmore, Peter A; Craig, David; McGuiness, Bernadette; Todd, Stephen; Johnston, Janet A; Holmes, Clive; Mann, David; Smith, A David; Love, Seth; Kehoe, Patrick G; Hardy, John; Mead, Simon; Fox, Nick; Rossor, Martin; Collinge, John; Livingston, Gill; Bass, Nicholas J; Gurling, Hugh; McQuillin, Andrew; Jones, Lesley; Holmans, Peter A; O'Donovan, Michael; Owen, Michael J; Williams, Julie; Morgan, Kevin
Data(s)

01/12/2011
Resumo

We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.
Identificador

http://pure.qub.ac.uk/portal/en/publications/no-evidence-that-extended-tracts-of-homozygosity-are-associated-with-alzheimers-disease(4714097f-348b-4383-8e95-e0a155860b7d).html

http://dx.doi.org/10.1002/ajmg.b.31216
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Sims , R , Dwyer , S , Harold , D , Gerrish , A , Hollingworth , P , Chapman , J , Jones , N , Abraham , R , Ivanov , D , Pahwa , J S , Moskvina , V , Dowzell , K , Thomas , C , Stretton , A , Lovestone , S , Powell , J , Proitsi , P , Lupton , M K , Brayne , C , Rubinsztein , D C , Gill , M , Lawlor , B , Lynch , A , Brown , K S , Passmore , P A , Craig , D , McGuiness , B , Todd , S , Johnston , J A , Holmes , C , Mann , D , Smith , A D , Love , S , Kehoe , P G , Hardy , J , Mead , S , Fox , N , Rossor , M , Collinge , J , Livingston , G , Bass , N J , Gurling , H , McQuillin , A , Jones , L , Holmans , P A , O'Donovan , M , Owen , M J , Williams , J & Morgan , K 2011 , ' No Evidence that Extended Tracts of Homozygosity are Associated with Alzheimer’s Disease. ' AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS , vol 156 , no. 7 , pp. 764-771 . DOI: 10.1002/ajmg.b.31216
Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2716 #Genetics(clinical) #/dk/atira/pure/subjectarea/asjc/2700/2738 #Psychiatry and Mental health #/dk/atira/pure/subjectarea/asjc/2800/2804 #Cellular and Molecular Neuroscience
Tipo

article
Acesso ao item digital