Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches


Autoria(s): Duprey, J.L.H.A.; Bassani, D.M.; Hyde, E.I.; Ludwig, C.; Rodger, A.; Vyle, Joseph; Wilkie, J.; Zhao, Z.Y.; Tucker, J.H.R.
Data(s)

01/03/2011

Resumo

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

Identificador

http://pure.qub.ac.uk/portal/en/publications/anthracenemodified-oligonucleotides-as-fluorescent-dna-mismatch-sensors-discrimination-between-various-basepair-mismatches(ed359755-e505-4129-85dd-0f3192403871).html

http://dx.doi.org/10.1080/10610278.2010.523117

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Duprey , J L H A , Bassani , D M , Hyde , E I , Ludwig , C , Rodger , A , Vyle , J , Wilkie , J , Zhao , Z Y & Tucker , J H R 2011 , ' Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches ' SUPRAMOLECULAR CHEMISTRY , vol 23 , no. 3-4 , pp. 273-277 . DOI: 10.1080/10610278.2010.523117

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1600 #Chemistry(all)
Tipo

article