Biaryl polyamides as a new class of DNA quadruplex-binding ligands
| Data(s) |
2009
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|---|---|
| Resumo |
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Rahman , K M , Reszka , A P , Gunaratnam , M , Haider , S , Howard , P W , Fox , K R , Neidle , S & Thurston , D E 2009 , ' Biaryl polyamides as a new class of DNA quadruplex-binding ligands ' Chemical Communications , vol 27 , no. 27 , pp. 4097-4099 . DOI: 10.1039/b902359c |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2500/2506 #Metals and Alloys #/dk/atira/pure/subjectarea/asjc/2500/2505 #Materials Chemistry #/dk/atira/pure/subjectarea/asjc/2500/2508 #Surfaces, Coatings and Films #/dk/atira/pure/subjectarea/asjc/2500/2504 #Electronic, Optical and Magnetic Materials #/dk/atira/pure/subjectarea/asjc/2500/2503 #Ceramics and Composites #/dk/atira/pure/subjectarea/asjc/1500/1503 #Catalysis #/dk/atira/pure/subjectarea/asjc/1600 #Chemistry(all) |
| Tipo |
article |
