Detection of epidermal growth factor receptor variations by partially denaturing HPLC
| Data(s) |
01/01/2007
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| Resumo |
Background: Epidermal growth factor receptor gene (EGFR) variants may be useful markers for identifying responders to gefitinib and erlotinib, small-molecule tyrosine kinase inhibitors of EGFR; therefore, sensitive and cost-effective assays are needed to detect EGFR variants in routine clinical samples. We have developed a partially denaturing HPLC (pDHPLC) assay that is superior to direct sequencing with respect to detection limits, costs, and time requirements. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Chin , T M , Anuar , D , Soo , R , Salto-Tellez , M , Li , W Q , Ahmad , B , Lee , S C , Goh , B C , Kawakami , K , Segal , A , Iacopetta , B & Soong , R 2007 , ' Detection of epidermal growth factor receptor variations by partially denaturing HPLC ' Clinical Chemistry , vol 53 , no. 1 , pp. 62-70 . DOI: 10.1373/clinchem.2006.074831 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1308 #Clinical Biochemistry |
| Tipo |
article |
