Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
| Data(s) |
01/05/2008
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| Resumo |
Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to 5-FU treatment. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Soong , R , Shah , N , Salto-Tellez , M , Tai , B C , Soo , R A , Han , H C , Ng , S S , Tan , W L , Zeps , N , Joseph , D , Diasio , R B & Iacopetta , B 2008 , ' Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy ' Annals of Oncology , vol 19 , no. 5 , pp. 915-919 . DOI: 10.1093/annonc/mdm599 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research |
| Tipo |
article |
