Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?


Autoria(s): Chen, Q.; Wang, X.; O'Neill, Francis; Walsh, D.; Kendler, K.S.; Chen, X.N.
Data(s)

01/12/2008

Resumo

Background: The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5'monophosphoramidate substrates such as AMP-morpholidate. The human HINT1 gene is located on chromosome 5q31.2, a region implicated in linkage studies of schizophrenia. HINT1 had been shown to have different expression in postmortem brains between schizophrenia patients and unaffected controls. It was also found to be associated with the dysregulation of postsynaptic dopamine transmission, thus suggesting a potential role in several neuropsychiatric diseases.

Identificador

http://pure.qub.ac.uk/portal/en/publications/is-the-histidine-triad-nucleotidebinding-protein-1-hint1-gene-a-candidate-for-schizophrenia(5263e6a1-9d4f-4408-8ed4-c015580562f0).html

http://dx.doi.org/10.1016/j.schres.2008.08.006

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Chen , Q , Wang , X , O'Neill , F , Walsh , D , Kendler , K S & Chen , X N 2008 , ' Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia? ' Schizophrenia Research , vol 106 , no. 2-3 , pp. 200-207 . DOI: 10.1016/j.schres.2008.08.006

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2738 #Psychiatry and Mental health #/dk/atira/pure/subjectarea/asjc/2800/2803 #Biological Psychiatry
Tipo

article