Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

Autoria(s): Osorio, A.; Milne, R.L.; Pita, G.; Peterlongo, P.; Heikkinen, T.; Simard, J.; Chenevix-Trench, G.; Spurdle, A.B.; Beesley, J.; Chen, X.; Healey, S.; Neuhausen, S.L.; Ding, Y.C.; Couch, F.J.; Wang, X.; Lindor, N.; Manoukian, S.; Barile, M.; Viel, A.; Tizzoni, L.; Szabo, C.I.; Foretova, L.; Zikan, M.; Claes, K.; Greene, M.H.; Mai, P.; Rennert, G.; Lejbkowicz, F.; Barnett-Griness, O.; Andrulis, I.L.; Ozcelik, H.; Weerasooriya, N.; Gerdes, A.M.; Thomassen, M.; Cruger, D.G.; Caligo, M.A.; Friedman, E.; Kaufman, B.; Laitman, Y.; Cohen, S.; Kontorovich, T.; Gershoni-Baruch, R.; Dagan, E.; Jernstrom, H.; Askmalm, M.S.; Arver, B.; Malmer, B.; Domchek, S.M.; Nathanson, K.L.; Brunet, J.; Cajal, T.R.Y.; Yannoukakos, D.; Hamann, U.; Hogervorst, F.B.L.; Verhoef, S.; Garcia, E.B.G.; Wijnen, J.T.; Van Den Ouweland, A.; Easton, D.F.; Peock, S.; Cook, M.; Oliver, C.T.; Frost, D.; Luccarini, C.; Evans, D.G.; Lalloo, F.; Eeles, R.; Pichert, G.; Cook, J.; Hodgson, S.; Morrison, Patrick; Douglas, F.; Godwin, A.K.; Sinilnikova, O.M.; Barjhoux, L.; Stoppa-Lyonnet, D.; Moncoutier, V.; Giraud, S.; Cassini, C.; Olivier-Faivre, L.; Revillion, F.; Peyrat, J.P.; Muller, D.; Fricker, J.P.; Lynch, H.T.; John, E.M.; Buys, S.; Daly, M.; Hopper, J.L.; Terry, M.B.; Miron, A.; Yassin, Y.; Goldgar, D.; Singer, C.F.; Gschwantler-Kaulich, D.; Pfeiler, G.; Spiess, A.C.; Hansen, T.V.; Johannsson, O.T.; Kirchhoff, T.; Offit, K.; Kosarin, K.; Piedmonte, M.; Rodriguez, G.C.; Wakeley, K.; Boggess, J.F.; Basil, J.; Schwartz, P.E.; Blank, S.V.; Toland, A.E.; Montagna, M.; Casella, C.; Imyanitov, E.N.; Allavena, A.; Schmutzler, R.K.; Versmold, B.; Engel, C.; Meindl, A.; Ditsch, N.; Arnold, N.; Niederacher, D.; Deissler, H.; Fiebig, B.; Varon-Mateeva, R.; Schaefer, D.; Froster, U.G.; Caldes, T.; De La Hoya, M.; McGuffog, L.; Antoniou, A.C.; Nevanlinna, H.; Radice, P.; Benitez, J.
Data(s)

01/12/2009
Resumo

BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers.
Identificador

http://pure.qub.ac.uk/portal/en/publications/evaluation-of-a-candidate-breast-cancer-associated-snp-in-ercc4-as-a-risk-modifier-in-brca1-and-brca2-mutation-carriers-results-from-the-consortium-of-investigators-of-modifiers-of-brca1brca2-cimba(cbece16e-dad6-43bf-9b1b-c6a139d2a02f).html

http://dx.doi.org/10.1038/sj.bjc.6605416
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Osorio , A , Milne , R L , Pita , G , Peterlongo , P , Heikkinen , T , Simard , J , Chenevix-Trench , G , Spurdle , A B , Beesley , J , Chen , X , Healey , S , Neuhausen , S L , Ding , Y C , Couch , F J , Wang , X , Lindor , N , Manoukian , S , Barile , M , Viel , A , Tizzoni , L , Szabo , C I , Foretova , L , Zikan , M , Claes , K , Greene , M H , Mai , P , Rennert , G , Lejbkowicz , F , Barnett-Griness , O , Andrulis , I L , Ozcelik , H , Weerasooriya , N , Gerdes , A M , Thomassen , M , Cruger , D G , Caligo , M A , Friedman , E , Kaufman , B , Laitman , Y , Cohen , S , Kontorovich , T , Gershoni-Baruch , R , Dagan , E , Jernstrom , H , Askmalm , M S , Arver , B , Malmer , B , Domchek , S M , Nathanson , K L , Brunet , J , Cajal , T R Y , Yannoukakos , D , Hamann , U , Hogervorst , F B L , Verhoef , S , Garcia , E B G , Wijnen , J T , Van Den Ouweland , A , Easton , D F , Peock , S , Cook , M , Oliver , C T , Frost , D , Luccarini , C , Evans , D G , Lalloo , F , Eeles , R , Pichert , G , Cook , J , Hodgson , S , Morrison , P , Douglas , F , Godwin , A K , Sinilnikova , O M , Barjhoux , L , Stoppa-Lyonnet , D , Moncoutier , V , Giraud , S , Cassini , C , Olivier-Faivre , L , Revillion , F , Peyrat , J P , Muller , D , Fricker , J P , Lynch , H T , John , E M , Buys , S , Daly , M , Hopper , J L , Terry , M B , Miron , A , Yassin , Y , Goldgar , D , Singer , C F , Gschwantler-Kaulich , D , Pfeiler , G , Spiess , A C , Hansen , T V , Johannsson , O T , Kirchhoff , T , Offit , K , Kosarin , K , Piedmonte , M , Rodriguez , G C , Wakeley , K , Boggess , J F , Basil , J , Schwartz , P E , Blank , S V , Toland , A E , Montagna , M , Casella , C , Imyanitov , E N , Allavena , A , Schmutzler , R K , Versmold , B , Engel , C , Meindl , A , Ditsch , N , Arnold , N , Niederacher , D , Deissler , H , Fiebig , B , Varon-Mateeva , R , Schaefer , D , Froster , U G , Caldes , T , De La Hoya , M , McGuffog , L , Antoniou , A C , Nevanlinna , H , Radice , P & Benitez , J 2009 , ' Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) ' British Journal of Cancer , vol 101 , no. 12 , pp. 2048-2054 . DOI: 10.1038/sj.bjc.6605416
Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology
Tipo

article
Acesso ao item digital