Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation


Autoria(s): Singh, I.; Vyle, Joseph; Heaney, F.
Data(s)

2009

Resumo

Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

Identificador

http://pure.qub.ac.uk/portal/en/publications/fast-copperfree-click-chemistry-a-convenient-solidphase-approach-to-oligonucleotide-conjugation(11cc67aa-0514-4b84-b6b4-e4c9fac2b640).html

http://dx.doi.org/10.1039/b904185k

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Singh , I , Vyle , J & Heaney , F 2009 , ' Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation ' Chemical Communications , vol 22 , no. 22 , pp. 3276-3278 . DOI: 10.1039/b904185k

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1500/1503 #Catalysis #/dk/atira/pure/subjectarea/asjc/1600 #Chemistry(all) #/dk/atira/pure/subjectarea/asjc/2500/2503 #Ceramics and Composites #/dk/atira/pure/subjectarea/asjc/2500/2504 #Electronic, Optical and Magnetic Materials #/dk/atira/pure/subjectarea/asjc/2500/2505 #Materials Chemistry #/dk/atira/pure/subjectarea/asjc/2500/2506 #Metals and Alloys #/dk/atira/pure/subjectarea/asjc/2500/2508 #Surfaces, Coatings and Films
Tipo

article