Statins for the treatment of dementia
| Data(s) |
2010
|
|---|---|
| Formato |
application/pdf |
| Identificador |
http://dx.doi.org/10.1002/14651858.CD007514.pub2 http://www.scopus.com/inward/record.url?scp=77955971753&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Publicador |
Unknown Publisher |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
McGuinness , B , O'Hare , J , Craig , D , Bullock , R , Malouf , R & Passmore , P 2010 , ' Statins for the treatment of dementia ' Cochrane Database of Systematic Reviews , vol 4 , no. 8 , pp. CD007514 . DOI: 10.1002/14651858.CD007514.pub2 |
| Tipo |
article |
| Resumo |
The use of statin therapy in established Alzheimer's disease (AD) or vascular dementia (VaD) is a relatively unexplored area. In AD ss-amyloid protein (Ass) is deposited in the form of extracellular plaques and previous studies have determined Ass generation is cholesterol dependent. Hypercholesterolaemia has also been implicated in the pathogenesis of VaD. Due to the role of statins in cholesterol reduction it is biologically plausible they may be efficacious in the treatment of AD and dementia. |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700 #Medicine(all) |
