Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids.

Autoria(s): Buckle, D.R.; Cantello, B.C.C.; Cawthorne, M.A.; Coyle, P.J.; Dean, D.K.; Faller, A.; Haigh, David; Hindley, R.M.; Jefcott, L.; Lister, C.A.; Pinto, I.L.; Rami, H.K.; Smith, D.G.; Smith, S.A.
Data(s)

1996
Resumo

A review with 22 refs. The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitizing antidiabetic agents can be replaced by a range of ?-heteroatom functionalized ?-phenylpropanoic acids. ?-Oxy-carboxylic acids show potent antidiabetic activity and one compd., the ?-ethoxyacid (SB 213068), is one of the most potent antihyperglycemic agents yet reported.
Identificador

http://pure.qub.ac.uk/portal/en/publications/nonthiazolidinedione-antihyperglycemic-agents-1-alphaheteroatom-substitutedbetaphenylpropanoic-acids(8556290b-f55f-49d8-b880-8b7f1d70f6d7).html
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Buckle , D R , Cantello , B C C , Cawthorne , M A , Coyle , P J , Dean , D K , Faller , A , Haigh , D , Hindley , R M , Jefcott , L , Lister , C A , Pinto , I L , Rami , H K , Smith , D G & Smith , S A 1996 , ' Non-thiazolidinedione antihyperglycemic agents. 1: Alpha-Heteroatom substituted-beta-phenylpropanoic acids. ' Bioorganic & Medicinal Chemistry Letters , vol 6 , pp. 2121-2126 .
Tipo

article
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