Non-thiazolidinedione antihyperglycemic agents. 2: alpha-Carbon substituted-beta-phenylpropanoic acids.

Autoria(s): Buckle, D.R.; Cantello, B.C.C.; Cawthorne, M.A.; Coyle, P.J.; Dean, D.K.; Faller, A.; Haigh, David; Hindley, R.M.; Jefcott, L.J.; Lister, C.A.; Pinto, I.L.; Rami, H.K.; Smith, D.G.; Smith, S.A.
Data(s)

1996
Resumo

Buckle, D. R.; Cantello, B. C. C.; Cawthorne, M. A.; Coyle, P. J.; Dean, D. K.; Faller, A.; Haigh, D.; Hindley, R. M.; Lefcott, L. J.; et al. Dep. Medicinal Chem., Smithkline Beecham Pharmaceuticals, Surrey, UK. Bioorganic & Medicinal Chemistry Letters (1996), 6(17), 2127-2130. Publisher: Elsevier, CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 125:238227 AN 1996:573179 CAPLUS (Copyright (C) 2009 ACS on SciFinder (R)) Abstract The thiazolidine-2,4-dione ring of insulin-sensitizing antidiabetic agents can be replaced by ?-acyl-, ?-alkyl- and ?-(aralkyl)-carboxylic acids. The inclusion of an addnl. lipophilic moiety affords compds., equipotent to BRL 48482.
Identificador

http://pure.qub.ac.uk/portal/en/publications/nonthiazolidinedione-antihyperglycemic-agents-2-alphacarbon-substitutedbetaphenylpropanoic-acids(6189155b-6eec-4845-b2eb-aa1ba0d474f6).html
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Buckle , D R , Cantello , B C C , Cawthorne , M A , Coyle , P J , Dean , D K , Faller , A , Haigh , D , Hindley , R M , Jefcott , L J , Lister , C A , Pinto , I L , Rami , H K , Smith , D G & Smith , S A 1996 , ' Non-thiazolidinedione antihyperglycemic agents. 2: alpha-Carbon substituted-beta-phenylpropanoic acids. ' Bioorganic & Medicinal Chemistry Letters , vol 6 , pp. 2127-2130 .
Tipo

article
Acesso ao item digital