 -Hydroxypiperidinecarboxylates: additions to the chiral pool from bakers' yeast reductions of  -ketopiperidinecarboxylates.


Autoria(s): Knight, D.W.; Lewis, N.; Share, A.C.; Haigh, David
Data(s)

1998

Resumo

Knight, David W.; Lewis, Neil; Share, Andrew C.; Haigh, David. Chemistry Department, University of Nottingham, Nottingham, UK. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1998), (22), 3673-3684. Publisher: Royal Society of Chemistry, CODEN: JCPRB4 ISSN: 0300-922X. Journal written in English. CAN 130:153545 AN 1998:715806 CAPLUS (Copyright (C) 2009 ACS on SciFinder (R)) Abstract Redn. of the piperidine keto esters, e.g., I, using fermenting bakers' yeast provides high yields of the corresponding hydroxy esters, e.g., II, exclusively as the cis-diastereoisomers and with good levels (?80%) of enantiomeric enrichment. The relative stereochemistries of the products were deduced from NMR data while the abs. configurations were detd. by degrdn. to known piperidinemethanol derivs. or, in the case of hydroxy ester III, by homologation to (R)-3-quinuclidinol IV.

Identificador

http://pure.qub.ac.uk/portal/en/publications/-hydroxypiperidinecarboxylates-additions-to-the-chiral-pool-from-bakers-yeast-reductions-of--ketopiperidinecarboxylates(4094c0c5-6e45-4fea-b2b6-8d84249a6403).html

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Knight , D W , Lewis , N , Share , A C & Haigh , D 1998 , '  -Hydroxypiperidinecarboxylates: additions to the chiral pool from bakers' yeast reductions of  -ketopiperidinecarboxylates. ' Journal of the Chemical Society - Perkin Transactions 1 , vol - , pp. 3673-3684 .

Tipo

article