The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.
| Data(s) |
01/11/1999
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|---|---|
| Resumo |
Aryl hydroxylamine derivs. have been synthesized that are some of the most potent inhibitors of hCMV protease prepd. to date (IC50 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138. |
| Identificador |
http://www.scopus.com/inward/record.url?scp=0033229859&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Smith , D G , Gribble , A D , Haigh , D , Ife , R J , Lavery , P , Skett , P , Slingsby , B P , Stacey , R , Ward , R W & West , A 1999 , ' The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives. ' Bioorganic & Medicinal Chemistry Letters , vol 9(21) , no. 21 , pp. 3137-3142 . |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery #/dk/atira/pure/subjectarea/asjc/3000/3003 #Pharmaceutical Science |
| Tipo |
article |
