3-anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)


Autoria(s): Smith, D.G.; Buffet, M.; Fenwick, A.E.; Haigh, David; Ife, R.J.; Saunders, M.; Slingsby, B.P.; Stacey, R.; Ward, R.W.
Data(s)

12/03/2001

Resumo

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases. (C) 2001 Elsevier Science Ltd. All rights reserved.

Identificador

http://pure.qub.ac.uk/portal/en/publications/3anilino4arylmaleimides-potent-and-selective-inhibitors-of-glycogen-synthase-kinase3-gsk3(ea0fff26-9443-4183-8863-1c074fe4cc7c).html

http://www.scopus.com/inward/record.url?scp=0035848403&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Smith , D G , Buffet , M , Fenwick , A E , Haigh , D , Ife , R J , Saunders , M , Slingsby , B P , Stacey , R & Ward , R W 2001 , ' 3-anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) ' Bioorganic & Medicinal Chemistry Letters , vol 11 , no. 5 , pp. 635-639 .

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery #/dk/atira/pure/subjectarea/asjc/3000/3003 #Pharmaceutical Science
Tipo

article