Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate
| Data(s) |
08/03/2007
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|---|---|
| Resumo |
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties. |
| Identificador |
http://dx.doi.org/10.1021/jm061207r http://www.scopus.com/inward/record.url?scp=33847771635&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Slater , M J , Amphlett , E M , Andrews , D M , Bravi , G , Burton , G , Cheasty , A G , Corfield , J A , Ellis , M R , Fenwick , R H , Fernandes , S , Guidetti , R , Haigh , D , Hartley , C D , Howes , P D , Jackson , D L , Jarvest , R L , Lovegrove , V L H , Medhurst , K J , Parry , N R , Price , H , Shah , P , Singh , O M P , Stocker , R , Thommes , P , Wilkinson , C & Wonacott , A 2007 , ' Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate ' Journal of Medicinal Chemistry , vol 50 , no. 5 , pp. 897-900 . DOI: 10.1021/jm061207r |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry |
| Tipo |
article |
