Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity
| Data(s) |
01/04/2007
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| Resumo |
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta 21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon). (c) 2007 Elsevier Ltd. All rights reserved. |
| Identificador |
http://dx.doi.org/10.1016/j.bmcl.2007.01.034 http://www.scopus.com/inward/record.url?scp=33847658827&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Burton , G , Ku , T W , Carr , T J , Kiesow , T , Sarisky , R T , Lin-Goerke , J , Hofmann , G A , Slater , M J , Haigh , D , Dhanak , D , Johnson , V K , Parry , N R & Thommes , P 2007 , ' Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity ' Bioorganic & Medicinal Chemistry Letters , vol 17 , no. 7 , pp. 1930-1933 . DOI: 10.1016/j.bmcl.2007.01.034 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery #/dk/atira/pure/subjectarea/asjc/3000/3003 #Pharmaceutical Science |
| Tipo |
article |
