Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches


Autoria(s): Morrow, Desmond; McCarron, Paul; Woolfson, David; Juzenas, P.; Juzeniene, A.; Iani, V.; Moan, J.; Donnelly, Ryan
Data(s)

01/06/2010

Resumo

Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.

Identificador

http://pure.qub.ac.uk/portal/en/publications/influence-of-penetration-enhancers-on-topical-delivery-of-5aminolevulinic-acid-from-bioadhesive-patches(82ffefe4-e00f-4ad9-a952-1122ad9f988b).html

http://dx.doi.org/10.1211/jpp/62.06.0004

http://www.scopus.com/inward/record.url?scp=77953565911&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Morrow , D , McCarron , P , Woolfson , D , Juzenas , P , Juzeniene , A , Iani , V , Moan , J & Donnelly , R 2010 , ' Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches ' Journal of Pharmacy and Pharmacology , vol 62 , no. 6 , pp. 685-695 . DOI: 10.1211/jpp/62.06.0004

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/3000/3003 #Pharmaceutical Science #/dk/atira/pure/subjectarea/asjc/3000/3004 #Pharmacology
Tipo

article