Mechanistic studies on human N-acetylgalactosamine kinase
| Data(s) |
2010
|
|---|---|
| Resumo |
N-Acetylgalactosamine kinase (GALK2) is a small molecule kinase from the GHMP family which phosphorylates N-acetylgalactosamine at the expense of ATP. Recombinant GALK2 expressed in, and purified from, Escherichia coli was shown to be active with the following kinetic parameters: Michaelis constant for ATP, 14 +/- 3 mu M; Michaelis constant for N-acetylgalactosamine, 40 +/- 14 mu M; and turnover number, 1.0 +/- 0.1 s |
| Identificador |
http://dx.doi.org/10.3109/14756360903179492 http://www.scopus.com/inward/record.url?scp=77951489545&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Agnew , A & Timson , D 2010 , ' Mechanistic studies on human N-acetylgalactosamine kinase ' Journal of Enzyme Inhibition and Medicinal Chemistry , vol 25 , no. 3 , pp. 370-376 . DOI: 10.3109/14756360903179492 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery #/dk/atira/pure/subjectarea/asjc/3000/3004 #Pharmacology |
| Tipo |
article |
