Contribution of 30 Biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: The MONICA, risk, genetics, archiving and monograph (MORGAM) biomarker project


Autoria(s): Blankenberg, S.; Zeller, T.; Saarela, O.; Havulinna, A.S.; Kee, Frank; Tunstall Pedoe, H.; Kuulasmaa, K.; Yarnell, John; Schnabel, R.B.; Wild, P.S.; Munzel, T.F.; Lackner, K.J.; Tiret, L.; Evans, Alun; Salomaa, V.
Data(s)

08/06/2010

Resumo

Background— Cardiovascular risk estimation by novel biomarkers needs assessment in disease-free population cohorts, followed up for incident cardiovascular events, assaying the serum and plasma archived at baseline. We report results from 2 cohorts in such a continuing study.<br/>Methods and Results— Thirty novel biomarkers from different pathophysiological pathways were evaluated in 7915 men and women of the FINRISK97 population cohort with 538 incident cardiovascular events at 10 years (fatal or nonfatal coronary or stroke events), from which a biomarker score was developed and then validated in the 2551 men of the Belfast Prospective Epidemiological Study of Myocardial Infarction (PRIME) cohort (260 events). No single biomarker consistently improved risk estimation in FINRISK97 men and FINRISK97 women and the Belfast PRIME Men cohort after allowing for confounding factors; however, the strongest associations (with hazard ratio per SD in FINRISK97 men) were found for N-terminal pro-brain natriuretic peptide (1.23), C-reactive protein (1.23), B-type natriuretic peptide (1.19), and sensitive troponin I (1.18). A biomarker score was developed from the FINRISK97 cohort with the use of regression coefficients and lasso methods, with selection of troponin I, C-reactive protein, and N-terminal pro-brain natriuretic peptide. Adding this score to a conventional risk factor model in the Belfast PRIME Men cohort validated it by improved c-statistics (P=0.004) and integrated discrimination (P<0.0001) and led to significant reclassification of individuals into risk categories (P=0.0008).<br/>Conclusions— The addition of a biomarker score including N-terminal pro-brain natriuretic peptide, C-reactive protein, and sensitive troponin I to a conventional risk model improved 10-year risk estimation for cardiovascular events in 2 middle-aged European populations. Further validation is needed in other populations and age groups.

Identificador

http://pure.qub.ac.uk/portal/en/publications/contribution-of-30-biomarkers-to-10year-cardiovascular-risk-estimation-in-2-population-cohorts-the-monica-risk-genetics-archiving-and-monograph-morgam-biomarker-project(0ac114d2-80cf-4ac8-b5e6-e5e26ca200df).html

http://dx.doi.org/10.1161/CIRCULATIONAHA.109.901413

http://www.scopus.com/inward/record.url?scp=77953356167&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Blankenberg , S , Zeller , T , Saarela , O , Havulinna , A S , Kee , F , Tunstall Pedoe , H , Kuulasmaa , K , Yarnell , J , Schnabel , R B , Wild , P S , Munzel , T F , Lackner , K J , Tiret , L , Evans , A & Salomaa , V 2010 , ' Contribution of 30 Biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: The MONICA, risk, genetics, archiving and monograph (MORGAM) biomarker project ' Circulation , vol 121 , no. 22 , pp. 2388-2397 . DOI: 10.1161/CIRCULATIONAHA.109.901413

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2737 #Physiology (medical) #/dk/atira/pure/subjectarea/asjc/2700/2705 #Cardiology and Cardiovascular Medicine
Tipo

article