Ligand differentiated complementary Rh-catalyst systems for the enantioselective desymmetrization of meso-cyclic anhydrides
| Data(s) |
18/04/2009
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|---|---|
| Resumo |
Two distinct systems for the rhodium-catalyzed enantioselective desymmetrization of meso-cyclic anhydrides have been developed. Each system has been optimized and are compatible with the use of in situ prepared organozinc reagents. Rhodium/PHOX species efficiently catalyze the addition of alkyl nucleophiles to glutaric anhydrides, while a rhodium/phosphoramidite system is effective in the enantioselective arylation of succinic and glutaric anhydrides. |
| Identificador |
http://dx.doi.org/10.1016/j.tet.2008.10.075 http://www.scopus.com/inward/record.url?scp=62049083853&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Johnson , J B , Cook , M & Rovis , T 2009 , ' Ligand differentiated complementary Rh-catalyst systems for the enantioselective desymmetrization of meso-cyclic anhydrides ' Tetrahedron , vol 65 , no. 16 , pp. 3202-3210 . DOI: 10.1016/j.tet.2008.10.075 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/3000/3002 #Drug Discovery |
| Tipo |
article |
