GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving K<sub>ATP</sub> and cAMP
Data(s) |
15/10/2008
|
---|---|
Resumo |
increasing evidence from both clinical and experimental studies indicates that the insulin-releasing hormone, glucagon-like peptide-1 (GLP-1) may exert additional protective/reparative effects on the cardiovascular system. The aim of this study was to examine vasorelaxant effects of GLP-1(7-36)amide, three structurally-related peptides and a non-peptide GLP-1 agonist in rat aorta. Interestingly, all GLP-1 compounds, including the established GLP-1 receptor antagonist, exendin (9-39) caused concentration-dependent relaxation. Mechanistic studies employing hyperpolarising concentrations of potassium or glybenclamide revealed that these relaxant effects are mediated via specific activation of ATP-sensitive potassium channels. Further experiments using a specific membrane-permeable cyclic AMP (cAMP) antagonist, and demonstration of increased cAMP production in response to GLP-1 illustrated the critical importance of this pathway. These data significantly extend previous observations suggesting that GLP-1 may modulate vascular function, and indicate that this effect may be mediated by the GLP-1 receptor. However, further studies are required in order to establish whether GLP-1 related agents may confer additional cardiovascular benefits to diabetic patients. (c) 2008 Elsevier Inc. All rights reserved. |
Formato |
application/pdf |
Identificador |
http://dx.doi.org/10.1016/j.abb.2008.08.001 http://pure.qub.ac.uk/ws/files/13031802/Green_et_al_Arch_Biochem_Biophys_2008.pdf http://www.scopus.com/inward/record.url?scp=52049093652&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Green , B D , Hand , K V , Dougan , J E , McDonnell , B M , Cassidy , R S & Grieve , D J 2008 , ' GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving K ATP and cAMP ' Archives of Biochemistry and Biophysics , vol 478 , no. 2 , pp. 136-142 . DOI: 10.1016/j.abb.2008.08.001 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1304 #Biophysics #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology |
Tipo |
article |