Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice
| Data(s) |
01/07/2007
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| Resumo |
Aims/hypothesis Ablation of gastric inhibitory polypeptide ( GIP) receptor action is reported to protect against obesity and associated metabolic abnormalities. The aim of this study was to use prediabetic ob/ob mice to examine whether 60 days of chemical GIP receptor ablation with (Pro(3)) GIP is able to counter the development of genetic obesity-related diabetes. |
| Identificador |
http://dx.doi.org/10.1007/s00125-007-0692-2 http://www.scopus.com/inward/record.url?scp=34249941340&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Irwin , N , McClean , P L , O'Harte , F P M , Gault , V A , Harriott , P & Flatt , P R 2007 , ' Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro(3))GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice ' Diabetologia , vol 50 , no. 7 , pp. 1532-1540 . DOI: 10.1007/s00125-007-0692-2 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2712 #Endocrinology, Diabetes and Metabolism #/dk/atira/pure/subjectarea/asjc/2700/2724 #Internal Medicine |
| Tipo |
article |
