Microbicide delivery: formulation technologies and strategies


Autoria(s): Malcolm, Karl
Data(s)

01/09/2008

Resumo

Purpose of review: The aim of this article is to summarize the latest information on microbicide formulations for prevention of sexual transmission of HIV infection in women. Recent findings: Although early microbicide formulations were conventionally coitally dependent gel products, new technologies are being developed for vaginal delivery of anti-HIV agents. Intravaginal rings for delivery of microbicides, for example, are being developed and evaluated clinically. Safety and acceptability data are available for many microbicide gels and for one microbicide intravaginal ring. Other microbicide formulations in development for once daily or other vaginal administration strategies include films, tablets, and ovules. Various microbicide formulations for rectal administration are also in development. Summary: New microbicide formulations in development are addressing many of the issues with the original gels such as coital dependency, frequency of use, acceptability, compliance, cost, and adaptability to large-scale production. All of these dosage forms are promising options for safe, effective, and acceptable microbicide products.

Identificador

http://pure.qub.ac.uk/portal/en/publications/microbicide-delivery-formulation-technologies-and-strategies(b5b25b66-e515-4015-a4e9-d712c97454f3).html

http://dx.doi.org/10.1097/COH.0b013e328305b96e

http://www.scopus.com/inward/record.url?scp=65549157434&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Malcolm , K 2008 , ' Microbicide delivery: formulation technologies and strategies ' Current Opinion in HIV and AIDS , vol 3 (5) , no. 5 , pp. 558-566 . DOI: 10.1097/COH.0b013e328305b96e

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2720 #Hematology #/dk/atira/pure/subjectarea/asjc/2900/2917 #Oncology(nursing) #/dk/atira/pure/subjectarea/asjc/2400/2403 #Immunology #/dk/atira/pure/subjectarea/asjc/2700/2725 #Infectious Diseases #/dk/atira/pure/subjectarea/asjc/2400/2406 #Virology #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology
Tipo

article