A randomised interventional trial of ω-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus


Autoria(s): Wright, S.; O'Prey, F.M.; Leahey, W.J.; Devine, A.B.; Johnston, Dennis; McVeigh, G.E.; McHenry, M.T.; Duffy, E.M.; Finch, M.B.; Bell, A.L.
Data(s)

01/06/2008

Resumo

Objective: To determine the clinical effect of dietary supplementation with low-dose ?-3-polyunsaturated fatty acids on disease activity and endothelial function in patients with systemic lupus erythematosus. Methods: A 24-week randomised double-blind placebo-controlled parallel trial of the effect of 3 g of ?-3-polyunsaturated fatty acids on 60 patients with systemic lupus erythematosus was performed. Serial measurements of disease activity using the revised Systemic Lupus Activity Measure (SLAM-R) and British Isles Lupus Assessment Group index of disease activity for systemic lupus erythematosus (BILAG), endothelial function using flow-mediated dilation (FMD) of the brachial artery, oxidative stress using platelet 8-isoprostanes and analysis of platelet membrane fatty acids were taken at baseline, 12 and 24 weeks. Results: In the fish oil group there was a significant improvement at 24 weeks in SLAM-R (from 9.4 (SD 3.0) to 6.3 (2.5), p

Identificador

http://pure.qub.ac.uk/portal/en/publications/a-randomised-interventional-trial-of-3polyunsaturated-fatty-acids-on-endothelial-function-and-disease-activity-in-systemic-lupus-erythematosus(2d8653a5-1657-4c1c-9d11-1fdca403fd7e).html

http://dx.doi.org/10.1136/ard.2007.077156

http://www.scopus.com/inward/record.url?scp=45149085801&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Wright , S , O'Prey , F M , Leahey , W J , Devine , A B , Johnston , D , McVeigh , G E , McHenry , M T , Duffy , E M , Finch , M B & Bell , A L 2008 , ' A randomised interventional trial of ω-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus ' Annals of the Rheumatic Diseases , vol 67 , no. 6 , pp. 841-848 . DOI: 10.1136/ard.2007.077156

Tipo

article