Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking
| Data(s) |
01/12/2007
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|---|---|
| Resumo |
Age-related macular degeneration (AMD) is the major cause of blindness in the elderly. Those with the neovascular end-stage of disease have irreversible loss of central vision. AMD is a complex disorder in which genetic and environmental factors play a role. Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology. We aimed to provide a model of disease risk based on these factors. |
| Formato |
application/pdf |
| Identificador |
http://dx.doi.org/10.1371/journal.pmed.0040355 http://www.scopus.com/inward/record.url?scp=38049086708&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
Hughes , A , Orr , N , Patterson , C , McConnell , V , Silvestri , G , Chakravarthy , U , Esfandiary , H & Hogg , R 2007 , ' Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking ' PLoS Medicine , vol 4 , no. 12 , pp. e355 . DOI: 10.1371/journal.pmed.0040355 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700 #Medicine(all) |
| Tipo |
article |
