New perspectives on neoplasia and the RNA world


Autoria(s): Hall, P A; Russell, S E H
Data(s)

01/06/2005

Resumo

<p>Key tenets of modern biology are the central place of protein in cell regulation and the flow of genetic information from DNA to RNA to protein. However, it is becoming increasingly apparent that genomes are much more complex than hitherto thought with remarkably complex regulatory systems. The notion that the fraction of the genome involved in coding protein is all that matters is increasingly being questioned as the roles of non-coding RNA (ncRNA) in cellular systems becomes recognised. The RNA world, including microRNA (miRNA), small inhibitory RNA (siRNA) and other RNA species, are now recognised as being crucial for the regulation of chromatin structure, gene expression, mRNA processing and splicing, mRNA stability and translational control. Furthermore such ncRNA systems may be perturbed in disease states and most notably in neoplasia, including in haematological malignancies. Here the burgeoning evidence for a role of miRNA in neoplasia is reviewed and the importance of understanding the RNA world emphasised. Copyright (c) 2005 John Wiley & Sons, Ltd.</p>

Identificador

http://pure.qub.ac.uk/portal/en/publications/new-perspectives-on-neoplasia-and-the-rna-world(b6a3ccfe-8624-46ee-8618-bc9075e7f2fa).html

http://dx.doi.org/10.1002/hon.748

http://www.scopus.com/inward/record.url?scp=28844491619&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Hall , P A & Russell , S E H 2005 , ' New perspectives on neoplasia and the RNA world ' Hematological Oncology , vol 23 , no. 2 , pp. 49-53 . DOI: 10.1002/hon.748

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research #/dk/atira/pure/subjectarea/asjc/2700/2720 #Hematology #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology
Tipo

article