Preparation of Potential Cell-Permeant Nucleoside-2',3'-Cyclic Phosphate Precursors


Autoria(s): Battaggia, S.; Smith, Emma; Vyle, Joseph
Data(s)

01/03/2007

Resumo

Uridine-3'-phosphorothiolate triesters bearing lipophilic moieties were prepared via Michaelis-Arbuzov chemistry. Subsequent deprotection of the S-cholesteryl phosphorothiolate triester afforded the corresponding diester which underwent spontaneous Cyclization to cleanly afford uridine 2',3'-cyclic phosphate. This transesterification reaction could be expedited by treatment with iodine under mild, neutral conditions.

Formato

application/pdf

Identificador

http://pure.qub.ac.uk/portal/en/publications/preparation-of-potential-cellpermeant-nucleoside23cyclic-phosphate-precursors(2ef5ac85-2eff-4d49-ac7b-01e8e01bdc3c).html

http://dx.doi.org/10.1080/15257770701257236

http://pure.qub.ac.uk/ws/files/428437/Battaggia_S%202007%20PSC%20thiolate.pdf

http://www.scopus.com/inward/record.url?scp=34147162233&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Battaggia , S , Smith , E & Vyle , J 2007 , ' Preparation of Potential Cell-Permeant Nucleoside-2',3'-Cyclic Phosphate Precursors ' Nucleosides Nucleotides & Nucleic Acids , vol 26 (3) , no. 3 , pp. 245-254 . DOI: 10.1080/15257770701257236

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1311 #Genetics
Tipo

article