Preparation of Potential Cell-Permeant Nucleoside-2',3'-Cyclic Phosphate Precursors
| Data(s) |
01/03/2007
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|---|---|
| Resumo |
Uridine-3'-phosphorothiolate triesters bearing lipophilic moieties were prepared via Michaelis-Arbuzov chemistry. Subsequent deprotection of the S-cholesteryl phosphorothiolate triester afforded the corresponding diester which underwent spontaneous Cyclization to cleanly afford uridine 2',3'-cyclic phosphate. This transesterification reaction could be expedited by treatment with iodine under mild, neutral conditions. |
| Formato |
application/pdf |
| Identificador |
http://dx.doi.org/10.1080/15257770701257236 http://pure.qub.ac.uk/ws/files/428437/Battaggia_S%202007%20PSC%20thiolate.pdf http://www.scopus.com/inward/record.url?scp=34147162233&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Battaggia , S , Smith , E & Vyle , J 2007 , ' Preparation of Potential Cell-Permeant Nucleoside-2',3'-Cyclic Phosphate Precursors ' Nucleosides Nucleotides & Nucleic Acids , vol 26 (3) , no. 3 , pp. 245-254 . DOI: 10.1080/15257770701257236 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry #/dk/atira/pure/subjectarea/asjc/1300/1311 #Genetics |
| Tipo |
article |
