Is screening for Factor V Leiden and Prothrombin G20210A Mutations in Renal Transplantation worthwhile? Results of a large single-center U.K. study


Autoria(s): Pherwani, A.D.; Winter, P.C.; McNamee, P.T.; Patterson, C.C.; Hill, C.M.; Connolly, J.K.; Maxwell, Alexander
Data(s)

15/08/2003

Resumo

This single center study is the largest series of renal transplant recipients and donors screened for the commonest prothrombotic genotypes. A total of 562 transplant recipients and 457 kidney donors were genotyped for the factor V Leiden and prothrombin G20210A mutations. The prevalence of heterozygous factor V Leiden was 3.4% and 2.6% and prothrombin G20210A was 2.0% and 1.1% in recipients and donors, respectively, similar frequencies to that of the general U.K. population. The 30-day and 1-year graft survival rates in recipients with thrombophilic mutations were 93% and 93%, compared with 88% and 82% in patients without these mutations (log-rank P =0.34). Thrombophilia in recipients (odds ratio 0.55; confidence interval 0.06-2.29; P =0.56) or in donors (odds ratio 1.53; confidence interval 0.27-5.74; P =0.46) did not correlate with graft loss at 30 days after transplantation. In contrast to recent reports, this study did not demonstrate an association between thrombophilia and renal allograft loss, and routine screening is not recommended.

Identificador

http://pure.qub.ac.uk/portal/en/publications/is-screening-for-factor-v-leiden-and-prothrombin-g20210a-mutations-in-renal-transplantation-worthwhile-results-of-a-large-singlecenter-uk-study(ba28baaa-3447-41c3-a571-b78f865a6a31).html

http://dx.doi.org/10.1097/01.TP.0000078896.75260.86

http://www.scopus.com/inward/record.url?scp=0042967956&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Pherwani , A D , Winter , P C , McNamee , P T , Patterson , C C , Hill , C M , Connolly , J K & Maxwell , A 2003 , ' Is screening for Factor V Leiden and Prothrombin G20210A Mutations in Renal Transplantation worthwhile? Results of a large single-center U.K. study ' Transplantation , vol 76(3) , no. 3 , pp. 603-605 . DOI: 10.1097/01.TP.0000078896.75260.86

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2747 #Transplantation #/dk/atira/pure/subjectarea/asjc/2400/2403 #Immunology
Tipo

article