Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma


Autoria(s): Stewart, J.P.; Thompson, Alexander; Santra, M.; Barlogie, B.; Lappin, Terence; Jr, Shaughnessy J.
Data(s)

01/07/2004

Resumo

The t(4;14)(p16;q32) translocation seen in c. 18% of newly diagnosed multiple myeloma (MM) cases, results in FGFR3 activation and creation of an IGH/MMSET fusion transcript. We have recently shown that FGFR3 is activated in only 75% of t(4;14)(+) cases, suggesting that alternative genes near the breakpoint may be involved in the transforming event. The gene, TACC3, located just 50 kb telomeric of FGFR3, with transforming capacity, therefore represented a candidate gene. Using a real-time quantitative polymerase chain reaction-based approach on a cohort of 54 patients, we found a statistically significant, twofold increase in TACC3 expression in t(4;14)(+) cases. TACC3, MMSET and p21 values were positively correlated in all cases and, of particular interest, six patient samples [three t(4;14)(-), three t(4;14)(+)] samples showed a joint up-regulation of TACC3, MMSET and p21. Although a poor prognosis is linked with elevated MMSET expression, an extended follow-up period will be required to evaluate the significance of elevated TACC3 and p21 expression in this subgroup of MM.

Identificador

http://pure.qub.ac.uk/portal/en/publications/correlation-of-tacc3-fgfr3-mmset-and-p21-expression-with-the-t414p163q32-in-multiple-myeloma(33d54a23-4b36-4a7c-b8a3-9decba8bee95).html

http://dx.doi.org/10.1111/j.1365-2141.2004.04996.x

http://www.scopus.com/inward/record.url?scp=3042834284&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Stewart , J P , Thompson , A , Santra , M , Barlogie , B , Lappin , T & Jr , S J 2004 , ' Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma ' British Journal of Haematology , vol 126 , no. 1 , pp. 72-76 . DOI: 10.1111/j.1365-2141.2004.04996.x

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2700/2720 #Hematology
Tipo

article