Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
| Data(s) |
01/09/2004
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| Resumo |
Glucosedependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine Kcells in response to nutrient absorption. In this study we have utilized a specific and enzymatically stable GIP receptor antagonist, (Pro(3))GIP, to evaluate the contribution of endogenous GIP to insulin secretion and glucose homeostasis in mice. Daily injection of (Pro(3))GIP (25 nmol/kg body weight) for 11 days had no effect on food intake or body weight. Nonfasting plasma glucose concentrations were significantly raised (p |
| Identificador |
http://dx.doi.org/10.1515/BC.2004.110 http://www.scopus.com/inward/record.url?scp=5044229968&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Irwin , N , Gault , V A , Green , B , Greer , B , McCluskey , J T , Harriott , P , OHarte , F P M & Flatt , P R 2004 , ' Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice ' Biological Chemistry , vol 385 , no. 9 , pp. 845-852 . DOI: 10.1515/BC.2004.110 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry |
| Tipo |
article |
