The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia


Autoria(s): Craig, David; Hart, Dominic; McCool, K.; McIlroy, S.P.; Passmore, Peter
Data(s)

01/07/2004

Resumo

The explanation for why some patients develop psychotic change in Alzheimer's disease (AD) is unclear. "Psychosis-modifier genes" may act in the setting of neurodegeneration to produce AD plus psychosis in a similar way to how genetic modulation during neurodevelopment leads to schizophrenia. Because there is increasing interest in the common disruption of cytokine pathways seen in both AD and schizophrenia, we tested the association between the functional interleukin-1beta -511 promoter polymorphism with delusions and hallucinations in AD. Significant associations between psychotic symptoms and the CC genotype (p = 0.001 - p = 0.043) and C allele (p = 0.014 vs p = 0.048) were found, thus confirming the previously noted increased risk in schizophrenia.

Identificador

https://pure.qub.ac.uk/portal/en/publications/the-interleukin-1beta-gene-promoter-polymorphism-511-acts-as-a-risk-factor-for-psychosis-in-alzheimers-dementia(dbb96bbf-7919-4d64-b566-cbf97e920c43).html

https://doi.org/10.1002/ana.20120

http://www.scopus.com/inward/record.url?scp=3042753372&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Craig , D , Hart , D , McCool , K , McIlroy , S P & Passmore , P 2004 , ' The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia ' , Annals of Neurology , vol. 56 , no. 1 , pp. 121-124 . https://doi.org/10.1002/ana.20120

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/2800 #Neuroscience(all)
Tipo

article