Reversible Photocontrol of Deoxyribozyme-Catalyzed RNA Cleavage under Multiple-Turnover Conditions


Autoria(s): Keiper, S.; Vyle, Joseph
Data(s)

12/04/2006

Resumo

Lights, camera, action! Photoswitchable nucleoside analogues containing o-, m-, or p-azobenzenes can be inserted in the catalytic core of RNA-cleaving 10-23 deoxyribozymes by replacing a nonconserved residue (see picture). Irradiation of the modified deoxyribozymes at 366 nm enhances RNA cleavage rates up to ninefold, thus achieving the rates observed for the unmodified deoxyribozyme.

Formato

application/pdf

application/pdf

Identificador

https://pure.qub.ac.uk/portal/en/publications/reversible-photocontrol-of-deoxyribozymecatalyzed-rna-cleavage-under-multipleturnover-conditions(5df8e717-4851-4417-8b24-7f306d267a4d).html

https://doi.org/10.1002/anie.200600164

https://pure.qub.ac.uk/ws/files/288387/z600164_s.pdf

http://www.scopus.com/inward/record.url?scp=33746217388&partnerID=8YFLogxK

http://www.scopus.com/inward/record.url?scp=33746217388&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/openAccess

Fonte

Keiper , S & Vyle , J 2006 , ' Reversible Photocontrol of Deoxyribozyme-Catalyzed RNA Cleavage under Multiple-Turnover Conditions ' , Angewandte Chemie International Edition , vol. 45 , no. 20 , pp. 3306-3309 . https://doi.org/10.1002/anie.200600164

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1600 #Chemistry(all)
Tipo

article