Idiotypic games within the immune network.


Autoria(s): Slaoui, Moncef; Vansanten, Georgette; Demeur, C; Leo, Oberdan; Marvel, J; Moser, Muriel; Tassignon, J; Greene, M.; Urbain, Jacques
Data(s)

01/04/1986

Resumo

In this paper, we have considered the problem of selection of available repertoires. With Ab2 as immunogens, we have used the idiotypic cascade to explore potential repertoires. Our results suggest that potential idiotypic repertoires are more or less the same within a species or between different species. A given idiotype "à la Oudin" can become a recurrent one within the same outbred species or within different species. Similarly, an intrastrain crossreactive idiotype can be induced in other strains, even though there is a genetic disparity between these strains. The structural basis of this phenomenon has been explored. We next examined results showing the loss and gain of recurrent idiotypes without any intentional idiotypic manipulation. A recurrent idiotype can be lost in a syngeneic transfer and a private one can become recurrent by changing the genetic background. The change of available idiotypic repertoires at the B cell level has profound influences on the idiotypic repertoires of suppressor T cells. All these results imply that idiotypic games are played by the immune system itself, a strong suggestion that the immune system is a functional idiotypic network.

Journal Article

Research Support, Non-U.S. Gov't

Review

SCOPUS: re.j

info:eu-repo/semantics/published

Formato

No full-text files

Identificador

uri/info:pmid/3084378

http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57288

Idioma(s)

en

Fonte

Immunological reviews, 90

Palavras-Chave #Sciences bio-médicales et agricoles #Animals #Antibody Formation #Genes #Immunity #Immunoglobulin Heavy Chains -- genetics #Immunoglobulin Idiotypes -- immunology #Immunoglobulin Variable Region -- genetics #Immunoglobulin Variable Region -- immunology #Mice #Mice, Inbred Strains #Mosaic Viruses -- immunology #Rabbits #p-Azobenzenearsonate -- immunology
Tipo

info:eu-repo/semantics/article

info:ulb-repo/semantics/articlePeerReview

info:ulb-repo/semantics/openurl/article